Cristiano Ronaldo scored twice as Portugal thrashed Poland 5-1 to reach the Nations League quarter-finals on Friday, while already-qualified Spain defeated Denmark.
Portugal wrapped up the top spot in Group A1 with a game to spare, securing their place in the next round in March.
France, Germany, and Italy are also already through to the last eight.
Poland were the better side early on but failed to take their chances in Porto and the home side made them pay, netting four times in the last 20 minutes.
Ronaldo volleyed over from close range shortly before the interval, as Portugal failed to register a shot on target in the first half.
Dominik Marczuk almost broke the deadlock in the 58th minute, but Portugal goalkeeper Diogo Costa produced a brilliant fingertip save to deny him.
The hosts broke from the resulting corner to score less than 60 seconds later, as Rafael Leao powered forward before finding Nuno Mendes, then continuing his run to meet the Paris Saint-Germain (PSG) full-back’s cross with a powerful header.
Portugal were awarded a penalty when Diogo Dalot’s strike flicked off Jakub Kiwior’s hand at point-blank range and was saved by Marcin Bulka.
Ronaldo stepped up to dink home a ‘Panenka’ spot-kick.
That goal ended any hopes Poland had of staging a comeback and Fernandes added a third for Portugal with 10 minutes left, crashing the ball in off the crossbar from just outside the box.
Pedro Neto also got on the scoresheet, collecting Ronaldo’s pass and rifling past Bulka at his near post.
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There was still time for Ronaldo to double his tally and move onto 135 international goals, acrobatically volleying home Vitinha’s cross from close range in the 87th minute.
Marczuk drilled in a consolation for Poland, but they can no longer qualify for the knock-out stages and will be relegated if they lose to Scotland next week.
In the other match in the group, Scotland gave their hopes of avoiding the drop a massive boost as John McGinn scored a late winner in a 1-0 victory over 10-man Croatia.
Petar Sucic was sent off in the first half, but Croatia almost hung on for the point they needed to qualify with Portugal, only for McGinn to strike in the 86th minute.
European champions Spain stayed unbeaten in Group A4 of the Nations League with a 2-1 win over Denmark in Copenhagen.
The other game in Group A4 saw Switzerland relegated by Aleksa Terzic’s late equaliser in a 1-1 draw with Serbia.
Romania’s Group C2 game against Kosovo in Bucharest was suspended in injury time and then abandoned with the game goalless after the visiting players walked off the pitch following chants of “Serbia” from the home fans.
“The UEFA Nations League match between Romania and Kosovo has been abandoned. UEFA will communicate further information in due course,” said governing body UEFA on its website.
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